Label-Free, Multi-Parametric Assessments of Cell Metabolism and Matrix Remodeling within Human and Early-Stage Murine Osteoarthritic Articular Cartilage

The authors used label-free two-photon excited fluorescence and second harmonic generation imaging to assess cellular and extracellular matrix features of murine articular cartilage during several time points at early stages of osteoarthritis development following destabilization of medial meniscus surgery.