Triumphs and Challenges in Exploiting poly(ADP-Ribose) Polymerase Inhibition to Combat Triple-Negative Breast Cancer

The authors discuss the roles of poly(ADP-ribose) polymerase (PARP) in mediating DNA repair processes in breast epithelial cells, mechanisms of PARPi resistance in TNBC, and recent advances in the development of agents designed to overcome PARPi resistance in TNBC.