Normalization of Tumor Vessels by Lenvatinib-Based Metallo-Nanodrugs Alleviates Hypoxia and Enhances Calreticulin-Mediated Immune Responses in Orthotopic HCC and Organoids

A targeted therapeutic strategy is presented for potentiating tumor vascular normalization and systematic chemo-immunotherapy to effectively inhibit the progression of hepatocellular carcinoma (HCC) in both orthotopic model and patients-derived organoids.