NewslettersHuman Immunology NewsCISH Impairs Lysosomal Function in Activated T Cells Resulting in Mitochondrial DNA Release and InflammagingBy Laurisa Dohm - April 18, 20230236Investigators showed that activated T cells from older adults contributed to inflammaging by releasing mitochondrial DNA into their environment due to an increased expression of the cytokine-inducible SH2-containing protein (CISH).[Nature Aging]Abstract