DRAG In Situ Barcoding Reveals an Increased Number of HSPCs Contributing to Myelopoiesis with Age

Hematopoietic stem and progenitor cell (HSPC) function had been mostly assessed using transplantation assays, and it remains unclear how HSPCs age in the native bone marrow niche. To address this issue, investigators presented an in situ single cell lineage tracing technology to quantify the clonal composition and cell production of single cells in their native niche.