Low Glucose Induced Alzheimer’s Disease-Like Biochemical Changes in Human Induced Pluripotent Stem Cell-Derived Neurons Is Due to Dysregulated O-GlcNAcylation

Investigators revealed that dysregulated O-GlcNAc, in part through mitochondrial dysfunction, caused the onset of sporadic Alzheimer’s disease (sAD)-like changes. They demonstrated the therapeutic potential of inhibiting O-GlcNAcase in alleviating AD-like biochemical changes.