NK Cell-Derived Extracellular Granzyme B Drives Epithelial Ulceration during HSV-2 Genital Infection

Using a mouse model of genital herpes simplex virus 2 (HSV-2) infection, scientists showed that interleukin-18 acted upon natural killer (NK) cells to promote accumulation of the serine protease granzyme B, coinciding with epithelial ulceration.