The eIF4EBP-eIF4E Axis Regulates CD4⁺ T Cell Differentiation through Modulation of T Cell Activation and Metabolism

As eIF4E is vital for eukaryotic translation, researchers examined how altered eIF4E activity affected T cell function using mice lacking eIF4E-binding proteins (BP-/-), finding that BP-/- effector T cells showed elevated Th1 responses ex vivo and upon viral challenge with enhanced Th1 differentiation observed in vitro.