Self-Organized Yolk Sac-Like Organoids Allow for Scalable Generation of Multipotent Hematopoietic Progenitor Cells from Induced Pluripotent Stem Cells

The authors found that hiPSCs cocultured with stromal cells as spheroids could grow in a stirred bioreactor and develop into yolk sac-like organoids without the addition of exogenous factors.