Pyruvate-Supported Flux through Medium-Chain Ketothiolase Promotes Mitochondrial Lipid Tolerance in Cardiac and Skeletal Muscles

Investigators combined a sophisticated mitochondrial phenotyping platform with state-of-the-art molecular profiling tools and multiple two-state mouse models of respiratory function to uncover a mechanism that connects AC accumulation to lipid intolerance, metabolic inflexibility, and respiratory inefficiency in skeletal muscle mitochondria.