Generation of Left Ventricle-Like Cardiomyocytes with Improved Structural, Functional, and Metabolic Maturity from Human Pluripotent Stem Cells

Scientists exploited cardiac development knowledge to instruct differentiation of hPSCs specifically toward left ventricle (LV) cardiomyocytes. Correct mesoderm patterning and retinoic acid pathway blocking are essential to generate near-homogenous LV-specific hPSC-derived cardiomycytes.