JMJD6 Protects against Isoproterenol-Induced Cardiac Hypertrophy via Inhibition of NF-κB Activation by Demethylating R149 of the p65 Subunit

Investigators demonstrated that JMJD6 overexpression significantly attenuated isoproterenol-induced hypertrophy in neonatal rat cardiomyocytes evidenced by the decreased cardiomyocyte surface area and hypertrophic genes expression.