iGEM as a Human iPS Cell-Based Global Epigenetic Modulation Detection Assay Provides Throughput Characterization of Chemicals Affecting DNA Methylation

Scientists developed an iPS cell-based global epigenetic modulation detection assay using hiPS cells that express a fluorescently labeled methyl-CpG-binding domain, which enables a high-throughput screening of epigenetic teratogens/mutagens.