NewslettersESC & iPSC NewsOct1 Cooperates with the Smad Family of Transcription Factors to Promote Mesodermal Lineage SpecificationBy lbeveridge - April 25, 20230135Using mouse ESCs with an inducible knockout of Oct1, investigators showed that Oct1 deficiency resulted in poor induction of mesoderm-specific genes, leading to impaired mesodermal and terminal muscle differentiation.[Science Signaling]Abstract