Reticulons Promote Formation of ER-Derived Double-Membrane Vesicles That Facilitate SARS-CoV-2 Replication

Researchers clarified how SARS-CoV-2 hijacks host factors to construct the double-membrane vesicles (DMVs). They showed that the endoplasmic reticulum (ER) morphogenic proteins reticulon-3 (RTN3) and RTN4 helped drive DMV formation, enabling viral replication.