The Myo-Inositol Biosynthesis Rate-Limiting Enzyme ISYNA1 Suppresses the Stemness of Ovarian Cancer via Notch1 Pathway

Scientists reported ISYNA1, the rate-limiting enzyme in myo-inositol biosynthesis, as a suppressor of ovarian cancer (OC) regulating cancer stemness, identifying ISYNA1 as a differentially expressed gene in normal ovary and ovarian cancer tissues, as well as OC cells and ovarian cancer stem cells.