Trehalose-Guanosine Glycopolymer Hydrogels Direct Adaptive Glia Responses in CNS Injury

Gglycopolymer-based supramolecular hydrogels were synthesized to direct adaptive glia repair after CNS injury. Combining poly(trehalose-co-guanosine) glycopolymers with free guanosine generated shear thinning hydrogels through stabilized formation of long-range G-quadruplex secondary structures.