MYC Drives Platinum Resistant SCLC That Is Overcome by the Dual PI3K-HDAC Inhibitor Fimepinostat

Elevated MYC expression following the acquisition of platinum resistance in vitro and in vivo was assessed. Moreover, the capacity of enforced MYC expression to drive platinum resistance was defined in small cell lung cancer cell lines and in a genetically engineered mouse model that expresses MYC specifically in lung tumors.