Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer

Investigators reported that the splicing factor SRSF1 was highly expressed in pancreatitis, pancreatic ductal adenocarcinoma (PDAC) precursor lesions, and tumors. Increased SRSF1 was sufficient to induce pancreatitis and accelerate KRASG12D-mediated PDAC.