Hypoxia Induces Downregulation of the Tumor-Suppressive sST2 in Colorectal Cancer Cells via the HIF–Nuclear IL-33–GATA3 Pathway

Investigators discovered that hypoxia reduced soluble ST2 (sST2) expression in colorectal cancer (CRC) cells and explored the associated molecular mechanisms, including the expression of key regulators of ST2 gene transcription in hypoxic CRC cells.