Cinnamaldehyde Induces Apoptosis and Enhances Anti-Colorectal Cancer Activity via Covalent Binding to HSPD1

The authors found that cinnamaldehyde (CA) could exert an antitumor effect in HCT-116 cell lines. Target fishing, molecular imaging, and live-cell tracing using an alkynyl–CA probe revealed that the heat shock 60 kDa protein 1 (HSPD1) protein was the target of CA.