Modeling Human Skeletal Development Using Human Pluripotent Stem Cells

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Scientists described a method that directed iPSC-derived sclerotome to chondroprogenitors in 3D pellet culture then to articular chondrocytes or, alternatively, along the growth plate cartilage pathway to become hypertrophic chondrocytes that could transition to osteoblasts.
[Proceedings Of The National Academy Of Sciences Of The United States Of America]
Abstract