Single-Cell Sequencing Reveals the Immune Microenvironment Landscape Related to Anti-PD-1 Resistance in Metastatic Colorectal Cancer with High Microsatellite Instability

The response of primary and metastatic lesions to first-line anti-PD-1 monotherapy was evaluated by radiology. Cells from primary lesions of patients with MSI-H/dMMR mCRC were analyzed using scRNA-seq.