Patient-Specific Induced Pluripotent Stem Cell Properties Implicate Ca²⁺-Homeostasis in Clinical Arrhythmia Associated with Combined Heterozygous RYR2 and SCN10A Variants

Scientists illustrate use of iPSCs as platforms for investigating cardiomyocyte phenotypes in a human family pedigree exemplified by novel heterozygous RYR2-A1855D and SCN10A-Q1362H variants occurring alone and in combination.