Monkeypox Virus Quadrivalent mRNA Vaccine Induces Immune Response and Protects against Vaccinia Virus

The authors developed two MPXV quadrivalent mRNA vaccines, named mRNA-A-LNP and mRNA-B-LNP, based on two intracellular mature virus specific proteins, A29L and M1R, and two extracellular enveloped virus specific proteins, A35R and B6R.