ASXL1 Mutations Accelerate Bone Marrow Fibrosis via EGR1-TNFA Axis-Mediated Neoplastic Fibrocyte Generation in Myeloproliferative Neoplasms

Scientists analyzed the clinical characteristics of ASXL1 mutations in myelofibrosis patients and generated hematopoietic-specific Asxl1 knockout and Jak2V617F knock-in mouse models.