Targeting MFAP5 in Cancer-Associated Fibroblasts Sensitizes Pancreatic Cancer to PD-L1-Based Immunochemotherapy via Remodeling the Matrix

Scientists found that prognostic microfibril associated protein 5 (MFAP5) was involved in activation of cancer-associated fibroblasts (CAFs). CAFs derived from both human and mouse PDAC tumors were isolated and cultured.