Schlafen 12 Restricts HIV-1 Latency Reversal by a Codon-Usage Dependent Post-Transcriptional Block in CD4⁺ T Cells

Within HIV-1-infected individuals, Schlafen 12 protein (SLFN12) expression in peripheral blood mononuclear cells correlated with HIV-1 plasma viral loads and proviral loads, suggesting a link with the general activation of the immune system.