The RNA Cap Methyltransferases RNMT and CMTR1 Co-Ordinate Gene Expression during Neural Differentiation

During neural differentiation, RNA guanine-7 methyltransferase (RNMT) was repressed and cap-specific mRNA (nucleoside-2′-O-)-methyltransferase 1 (CMTR1) was up-regulated. RNMT promoted expression of the pluripotency-associated gene products; repression of the RNMT complex (RNMT–RAM) is required for repression of these RNAs and proteins during differentiation.