Spatial Transcriptomic Analysis of Sonic Hedgehog Medulloblastoma Identifies That the Loss of Heterogeneity and Promotion of Differentiation Underlies the Response to CDK4/6 Inhibition

Investigators used spatially resolved transcriptomics to define the cellular diversity within a sonic hedgehog patient-derived model of medulloblastoma and showed that cells specific to a transcriptional state or spatial location are pivotal for CDK4/6 inhibitor, Palbociclib, treatment response.