cis-B7:CD28 Interactions at Invaginated Synaptic Membranes Provide CD28 Co-Stimulation and Promote CD8⁺ T Cell Function and Anti-Tumor Immunity

Scientists reported that CD8+ T cells displayed B7 ligands that interacted with CD28 in cis at membrane invaginations of the immunological synapse as a result of membrane remodeling driven by phosphoinositide-3-kinase and sorting-nexin-9.