Anti-Human-TIGIT Agonistic Antibody Ameliorates Autoimmune Diseases by Inhibiting Tfh and Tph Cells and Enhancing Treg Cells

Scientists generated anti-human-T cell immunoreceptor with Ig and ITIM domains (TIGIT) agonistic monoclonal antibodies (mAbs) and generated human-TIGIT knock-in mice to accurately evaluate the efficacy of mAb function.