Autophagy-Dependent Expression of Osteopontin and Its Downstream Stat3 Signaling Contributes to Lymphatic Malformation Progression to Lymphangiosarcoma

Using genetic tools to delete an essential autophagy gene Rb1cc1/FIP200 or its mutation specifically blocking its autophagy function, researchers demonstrated that autophagy inhibition abrogated lymphatic malformation progression to lymphangiosarcoma.