SUMO Specific Peptidase 3 Halts Pancreatic Ductal Adenocarcinoma Metastasis via deSUMOylating DKC1

Scientists dentified SUMO-specific protease 3 (SENP3) as a potential suppressor of PDAC progression through an in vivo metastatic model. Further studies revealed that SENP3 inhibited PDAC invasion in a SUMO system dependent fashion.