Pancreatic Cancer-Derived Small Extracellular Vesical Ezrin Activates Fibroblasts to Exacerbate Cancer Metastasis through STAT3 and YAP-1 Signaling Pathways

Investigators reported that ezrin expression in PDAC cell-derived small extracellular vesicles could activate fibroblasts, resulting in increased migration ability and high expression of α-SMA, PDGFRB, and high production of extracellular matrix in fibroblasts.