DYRK1A Inhibitors Leucettines and TGF-β Inhibitor Additively Stimulate Insulin Production in Beta Cells, Organoids, and Isolated Mouse Islets
Scientists showed that leucettines, known to be DYRK1A kinase inhibitors, could improve glucose-stimulated insulin secretion in rodent β-cells and isolated islets, as well as in human induced pluripotent stem cell-derived β-cells islets.
[Phytotherapy Research] To elucidate the underlying antitumor mechanism of lambertianic acid (LA) derived from Pinus koraiensis, the role of cancer metabolism related molecules was investigated in the apoptotic effect of LA in DU145 and PC3 prostate cancer cells.
[Frontiers In Pharmacology] Super enhancer-associated genes and transcription factors were identified from a cell line of metastatic castration-resistant prostate cancer (mCRPC) by the CUT&Tag assay. Differentially expressed genes between mCRPC and primary prostate cancer samples in the GSE35988 dataset were identified.
[Frontiers In Oncology] To facilitate the practical application of human embryonic stem cells (hESCs), scientists established a co-culture system consisting of prostate cancer cell lines and hESCs and investigated the antitumor activity of the supernatant of the co-culture system in vitro and in vivo.