DYRK1A Inhibitors Leucettines and TGF-β Inhibitor Additively Stimulate Insulin Production in Beta Cells, Organoids, and Isolated Mouse Islets

Scientists showed that leucettines, known to be DYRK1A kinase inhibitors, could improve glucose-stimulated insulin secretion in rodent β-cells and isolated islets, as well as in human induced pluripotent stem cell-derived β-cells islets.