iPSC-Derived Reactive Astrocytes From Patients With Multiple-Sclerosis Protect Cocultured Neurons in Inflammatory Conditions

Researchers generated induced pluripotent stem cells (iPSCs) to investigate possible mechanisms in benign multiple sclerosis (MS), compared to progressive MS. They differentiated neurons and astrocytes that were then stressed with inflammatory cytokines typically associated with MS.
[Journal Of Clinical Investigation]
AbstractGraphical Abstract