Neurofilament Accumulations in Amyotrophic Lateral Sclerosis Patients’ Motor Neurons Impair Axonal Initial Segment Integrity

To assess neurofilament accumulations and study the impact on motor neurons (MNs), investigators compared MNs derived from induced pluripotent stem cells of patients carrying mutations in C9orf72, SOD1 and TARDBP genes, the three main ALS genetic causes.