Cannabidiol Protects Dopaminergic-Like Neurons Against Paraquat- and Maneb-Induced Cell Death Through Safeguarding DJ-1CYS106 and Caspase 3 Independently of Cannabinoid Receptors: Relevance in Parkinson’s Disease
Menstrual stromal cell-derived dopamine-like neurons intoxicated with paraquat/maneb were used as a model system to elucidate the mechanism by which cannabidiol protects the neural cell from apoptosis in vitro.
[Haematologica] 301 patients with a median age 60 years were enrolled. Of them, 287 and 274 patients collected ≥2 and ≥4×106 CD34+ cells/kg, respectively, with a median of 9.9×106 CD34+ cells/kg collected.
[EMBO Journal] The authors provide an in-depth review of the metabolic and epigenetic interplay regulating hematopoietic stem cell fate, and discuss the influence of metabolic stress stimuli, as well as alterations occurring during leukemic development.