AZD5438 a GSK-3a/B and CDK Inhibitor Is Antiapoptotic Modulates Mitochondrial Activity and Protects Human Neurons From Mitochondrial Toxins

Experiments inhuman-inducedd pluripotent stem cell-derived cortical and midbrain neurons showed AZD5438 mediated significant protective effects, preventing neuronal cell death, and collapse in the neurite and mitochondrial network associated with rotenone treatment.