BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance
Investigators identified a mechanism mediated by sialyltransferases that induced an acidic tumor permissive microenvironment in BRCA1-mutant and most BRCA1-low breast cancers.
[Science Advances] Scientists used single-nucleus RNA sequencing to characterize a mouse model that mimicked human nonalcoholic steatohepatitis (NASH)–driven HCC, the MUP-uPA mouse fed a high-fat diet.
[JHEP Reports] Mouse liver perfusion was used to identify the effects of interstitial flow on hepatocyte proliferation ex vivo. Isolated hepatocytes in vitro were further exposed to varied shear stresses directly.
[JHEP Reports] Cholangiocarcinoma (CCA) tumor microenvironment was recapitulated on a microfluidic three-channel chip using primary CCA cells, cancer-associated fibroblasts, endothelial cells, and T cells isolated from CCA specimens.