Glucocorticoid Receptors Drive Breast Cancer Cell Migration and Metabolic Reprograming via PDK4

To understand the mechanisms of p-Ser134-GR action in the presence of glucocorticoid receptor (GR) agonists, the authors examined glucocorticoid-driven transcriptomes in CRISPR knock-in models of TNBC cells expressing wild-type or phospho-mutant GR.