Mir-183 Functions as an Oncogene via Decreasing PTEN in Breast Cancer Cells

Researchers investigated the molecular mechanism of miR-183 in breast cancer. Phosphatase and tensin homolog (PTEN) was validated by dual luciferase assay as a target gene of miR-183. Through qRT-PCR analysis, miR-183 and PTEN mRNA levels in breast cancer cell lines were measured.