ADAR1-Mediated RNA Editing of SCD1 Drives Drug Resistance and Self-Renewal in Gastric Cancer

Researchers established 5-fluorouracil and cisplatin resistant intestinal subtype gastric cancer patient-derived organoid lines. JAK/STAT signaling and its downstream, adenosine deaminases acting on RNA 1 (ADAR1), were shown to be concomitantly upregulated in the resistant lines.