PTTG1 Reprograms Asparagine Metabolism to Promote Hepatocellular Carcinoma Progression

Mechanistically, pituitary tumor transforming gene 1 (PTTG1) promoted asparagine synthetase transcription by binding to its promoter, and asparagine levels were correspondingly increased, which subsequently activated the mTOR pathway to facilitate HCC progression.
[Cancer Research]

Stay up-to-date with your field!

Subscribe for free weekly science newsletters.

Related News