PTTG1 Reprograms Asparagine Metabolism to Promote Hepatocellular Carcinoma Progression

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Mechanistically, pituitary tumor transforming gene 1 (PTTG1) promoted asparagine synthetase transcription by binding to its promoter, and asparagine levels were correspondingly increased, which subsequently activated the mTOR pathway to facilitate HCC progression.
[Cancer Research]
Abstract