Small Extracellular Vesicles Maintain Homeostasis of Senescent Mesenchymal Stem Cells at Least through Excreting Harmful Lipids

Investigators established a replicative senescence model of MSCs by successive passages and compared the phenotypic changes between pre-senescent MSCs (Pre-Sen MSCs) and Sen MSCs, and found that Sen MSCs exhibited a diminished adipogenic and osteogenic differentiation potential.