CXCR2 Expression during Melanoma Tumorigenesis Controls Transcriptional Programs That Facilitate Tumor Growth

The effects of a CXCR1/CXCR2 antagonist, SX-682, on melanoma tumorigenesis were evaluated in BrafV600E/Pten−/− and NRasQ61R/INK4a−/− mice and in melanoma cell lines.