Systematic Discovery of Transcription Factors That Improve hPSC-Derived Cardiomyocyte Maturation via Temporal Analysis of Bioengineered Cardiac Tissues

Researchers performed temporal transcriptome RNAseq analyses of progressively matured human pluripotent stem cell-derived cardiomyocytes across 2D and 3D differentiation systems and further compared these bioengineered tissues to native fetal and adult-derived tissues.