17-(R/S)-Hydroxyeicosatetraenoic Acid (HETE) Induces Cardiac Hypertrophy Through the CYP1B1 in Enantioselective Manners

Researchers investigated the effect of 17-HETE enantiomers on cardiac hypertrophy and cytochrome P450 1B1 (CYP1B1). Human adult cardiomyocyte cells were treated with 17-HETE enantiomers; cellular hypertrophy was evaluated by cell surface area and cardiac hypertrophy markers.