Human Skin-Resident CD8⁺ T Cells Require RUNX2 and RUNX3 for Induction of Cytotoxicity and Expression of the Integrin CD49a

The authors demonstrated enrichment of RUNT family transcription-factor-binding motifs in human epidermal CD8+CD103+CD49a+ TRM cells, paralleled by high RUNX2 and RUNX3 protein expression.